Annexin Homepage

ANNEXIN SEQUENCE DATABASE

Update: 10.03.2014

The Annexin Sequence Database is a curated compilation of annexin sequences with their current and "historical" nomenclatures, as well as links to individual entries in various nucleotide and amino acid sequence databases.

Main publications describing annexin phylogeny include:

Fernandez, M.P. & Morgan, R.O. (2003) Structure, function and evolution of the annexin gene superfamily. In: Annexins: biological importance and annexin-related pathologies (Bandorowicz-Pikula, J., editor.). Landes Bioscience, Georgetown, TX. pp. 21-37.
Clark G.B., Morgan R.O., Fernandez M. & Roux S.J. (2012) Evolutionary adaptation of plant annexins has diversified their molecular structures, interactions and functional roles. New Phytol 196, 695-712.
Cantacessi C., Seddon J.M., Miller T.M., Lee C.Y., Thomas L., Mason L., Willis C., Walker G., Loukas A., Gasser B., Jones M.K. & Hofmann A. (2013) A genome-wide analysis of annexins from parasitic organisms and their vectors. Sci. Rep. 3, 2893.

Search the Annexin Sequence Database.

The Current Nomenclature

A Annexins	Human and vertebrate orthologues 12 human subfamilies with orthologues in chordate metazoa
B Annexins	Non-vertebrate metazoans
C Annexins	Mycetozoa and fungi
D Annexins	Plants
E Annexins	Protista
F Annexins	Bacteria

Isoforms and Gene Duplications

Isoforms and gene duplications are indicated by small letters, and decimal numbers in case of species-specific gene duplications. Examples:

Annexins	Remark
ANXA2a / ANXA2b	cDNA isoforms a/b differ by 81 bp from untranslated exon 2
ANXA2.1 / ANXA2.2	decimal forms represent species-specific gene duplications
ANXA6a / ANXA6b	cDNA isoforms b have 6 extra codons encoded by cassette exon 21
ANXA7a / ANXA7b	cDNA isoforms b have 22 extra codons encoded by cassette exon 6
ANXA13a / ANXA13b	cDNA isoforms b have 41 extra codons encoded by cassette exon 2

Version 11: 18.09.13