Teaching 2002/2003
Update: 19.05.2017

Contents
Tutorials
Biological Sciences 3rd year module: Structure and Functions of Proteins, 2002-2003
Tutorial T1, 11.10.02Amino acids, peptide bonds, spectroscopy
Tutorial T2, 01.11.02Protein Folding
Downloads: Handout (PDF file)
Further reading, original literature and tutorials:
Pace, CN. (1990) Conformational stability of globular proteins. Trends Biochem. Sci. 15, 14-17.
The hydrophobic effect from: Schutt & Lindberg (2000) Anat. Rec. 261, 198-216.
Tutorial T3, 29.11.02Enzyme Mechanisms
Downloads: Questions/Answers (PDF file)
Tutorial T4, 10.01.03Membrane Structure
Downloads: Questions/Answers (PDF file)
Tutorial T5, 24.01.03Bioenergetics
Downloads: Questions/Answers (PDF file)
Lectures
Biochemistry/Molecular Biology/Genetics Honours: Basis of Molecular Recognition, Core 2002-2003
Lecture 8, 11.11.02The Structural Basis of Transcription: RNA Polymerase II
Downloads: Lecture (PDF file), Handout (PDF file)
Further reading, original literature and tutorials:
Cramer et al. (2000) Architecture of RNA polymerase II and implications for the transcription mechanism. Science 288, 640.
Cramer et al. (2001) Structural basis of transcription: RNA polymerase II at 2.8 Å resolution. Science 292, 1863.
Gnatt et al. (2001) Structural basis of transcription: An RNA polymerase II elongation complex at 3.3Å resolution. Science92, 1876.
Poglitsch et al. (1999) Electron crystal structure of an RNA polymerase II transcription elongationcomplex. Cell 98, 791.
Zhang & Darst (1998) Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain. Science 281, 262.
Zhang et al. (1999) Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Å resolution. Cell 98, 811.
Lecture 9, 18.11.02The Structural Basis of Translation: The Ribosome and Protein Synthesis
Downloads: Lecture (PDF file), Handout (PDF file)
Further reading, original literature and tutorials:
Gabashvili et al. (2000) Solution structure of the E. coli 70S ribosome at 11.5 Å resolution. Cell 100, 537-549.
Moore & Steitz (2002) The involvement of RNA in ribosome function. Nature 418, 229-235.
Wimberly et al. (2000) Structure of the 30S ribosomal subunit. Nature 407, 327-339.
Yusupov et al. (2001) Crystal structure of the ribosome at 5.5 Å resolution. Science 292, 883-896.