| Biological Sciences 3rd year module: Structure and Functions of Proteins, 2002-2003 |
| Tutorial T1, 11.10.02 | Amino acids, peptide bonds, spectroscopy |
| Tutorial T2, 01.11.02 | Protein Folding |
| Downloads: Handout (PDF file) |
| Further reading, original literature and tutorials: |
| Pace, CN. (1990) Conformational stability of globular proteins. Trends Biochem. Sci. 15, 14-17. |
| The hydrophobic effect from: Schutt & Lindberg (2000) Anat. Rec. 261, 198-216. |
| Tutorial T3, 29.11.02 | Enzyme Mechanisms |
| Downloads: Questions/Answers (PDF file) |
| Tutorial T4, 10.01.03 | Membrane Structure |
| Downloads: Questions/Answers (PDF file) |
| Tutorial T5, 24.01.03 | Bioenergetics |
| Downloads: Questions/Answers (PDF file) |
| Biochemistry/Molecular Biology/Genetics Honours: Basis of Molecular Recognition, Core 2002-2003 |
| Lecture 8, 11.11.02 | The Structural Basis of Transcription: RNA Polymerase II |
| Downloads: Lecture (PDF file), Handout (PDF file) |
| Further reading, original literature and tutorials: |
| Cramer et al. (2000) Architecture of RNA polymerase II and implications for the transcription mechanism. Science 288, 640. |
| Cramer et al. (2001) Structural basis of transcription: RNA polymerase II at 2.8 Å resolution. Science 292, 1863. |
| Gnatt et al. (2001) Structural basis of transcription: An RNA polymerase II elongation complex at 3.3Å resolution. Science92, 1876. |
| Poglitsch et al. (1999) Electron crystal structure of an RNA polymerase II transcription elongationcomplex. Cell 98, 791. |
| Zhang & Darst (1998) Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain. Science 281, 262. |
| Zhang et al. (1999) Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Å resolution. Cell 98, 811. |
| Lecture 9, 18.11.02 | The Structural Basis of Translation: The Ribosome and Protein Synthesis |
| Downloads: Lecture (PDF file), Handout (PDF file) |
| Further reading, original literature and tutorials: |
| Gabashvili et al. (2000) Solution structure of the E. coli 70S ribosome at 11.5 Å resolution. Cell 100, 537-549. |
| Moore & Steitz (2002) The involvement of RNA in ribosome function. Nature 418, 229-235. |
| Wimberly et al. (2000) Structure of the 30S ribosomal subunit. Nature 407, 327-339. |
| Yusupov et al. (2001) Crystal structure of the ribosome at 5.5 Å resolution. Science 292, 883-896. |