Teaching 2004/2005 |
Update: 15.08.2017 |
The BTO web site of the University of Edinburgh. The SFP course is managed online via WebCT. Tools: The web site of the European Bioinformatics Institute (EBI) provides a variety of services: http://www.ebi.ac.uk/. Rasmol is a free molecular viewer available for PC, Mac and UNIX platforms. Protein Explorer has been developed based on RasMol and is more powerful. The software is free and runs on PC, Mac and Linux platforms. Download of Chime may be required. Peptides is a stand-alone Java application for calculation of protein and peptide parameters. Databases: The PubMed database of scientific literature: http://www.ncbi.nlm.nih.gov/PubMed/. The GenBank database holds nucleotide and amino acid sequences: http://www.ncbi.nlm.nih.gov/GenBank/. The Protein Data Bank (PDB) is a repository for protein structures: http://www.rcsb.org/. |
Biological Sciences 3rd year module: Structure and Functions of Proteins, 2004-2005 | |
Tutorial 1, 27.09.04 | Amino acids, peptide bonds, spectroscopy |
Tutorial 2, 04.10.04 | Assignment of assessed course work |
Downloads: Tutorial notes | |
Tutorial 3, 18.10.04 | Protein Folding and Structure Determination |
Downloads: Tutorial notes | |
Tutorial 4, 01.11.04 | Quaternary structure, Histones, Polyelectrolyte theory |
Downloads: Answers, Khorasanizadeh (Cell 2004, 116, 259) | |
Tutorial 5, 15.11.04 | Enzyme Mechanisms |
Downloads: Tutorial notes | |
Tutorial 6, 29.11.04 | Membrane Structure |
Downloads: Tutorial notes |
Molecular Biology Honours: Structural Biology, 2004-2005 | |
Session 03.11.04 | Structural biology of cyclase-associated protein |
Downloads: Paper, Answers |
Biological Sciences 3rd year module: Structure and Functions of Proteins, 2004-2005 | |
Lecture 3, 30.09.04 | Protein Architecture |
Downloads: Lecture with Notes, Lecture Slides, Handout | |
Further reading, original literature and tutorials: | |
Further reading: Conformational energy calculations (from Introduction to Protein Science, A Lesk, 2004, p. 208ff) | |
Web tutorial: http://www.cryst.bbk.ac.uk/PPS2/course/ | |
Lecture 4, 04.10.04 | Protein Crystallography |
Downloads: Lecture Slides, Handout | |
Further reading, original literature and tutorials: | |
Teaching resources: http://www.iucr.org/cww-top/edu.index.html | |
Web tutorial: http://ruppweb.dyndns.org/ (X-ray crystallography tutorial) | |
Web tutorial: http://www.doe-mbi.ucla.edu/~sawaya/tutorials/tutorials.html (Cryst. tutorials) |
Biotechnology Honours: Enzymology, 2004-2005 | |
Enzymology 5, 05.10.04 | Membrane Enzymes |
Downloads: Lecture with Notes, Lecture Slides, Handout | |
Further reading, original literature and tutorials: | |
Giorno & Drioli (2000) Biocatalytic membrane reactors: applications and perspectives. TIBTECH 18, 339-349. | |
Sastry (2002) Entrapment of proteins and DNA in thermally evaporated lipid films. TIBTECH 20, 185-188. | |
Stahl & Uhlen (1997) Bacterial surface display: trends and progress. TIBTECH 15, 185-192. | |
Enzymology 6, 05.10.04 | Enzyme Encapsulation |
Downloads: Lecture with Notes, Lecture Slides, Handout | |
Further reading, original literature and tutorials: | |
Lasic (1998) Novel applications of liposomes. Trends Biotechnol. 16, 307. | |
Sawada & Ueda (2001) Enzyme processing of textiles in reverse micellar solution. J. Biotechnol. 89, 263. | |
Walde & Ichikawa (2001) Enzymes inside lipid vesicles: preparation, reactivity and applications. Biomol. Eng. 18, 143. |
Structural Biology: Studying Macromolecules in Health and Disease, 2004-2005 | |
Session 1, 05.10.04 | Lecture: Introduction, General Comments, UV/Vis Spectroscopy |
Downloads: Handout | |
Further reading, original literature and tutorials: | |
Exam paper 2003/04 | |
Exam paper 2003/04 (Answers) | |
Session 2, 12.10.04 | Practical: Peptide Properties; Lecture: Fluorescence Spectroscopy 1 |
Downloads: Handout | |
Session 3, 19.10.04 | Paper Presentations; Lecture: Fluorescence Spectroscopy 2 |
Downloads: Talks, Lecture, All | |
Session 4, 26.10.04 | Paper Presentations; Lecture: Fluorescence Spectroscopy 3 |
Downloads: Talks, Lecture, All | |
Further reading, original literature and tutorials: | |
Skriptum: "Methods in Structural Biochemistry" | |
Session 5, 02.11.04 | Lecture: CD Spectroscopy; Practical: Analysis of CD spectra |
Downloads: Handout | |
Session 6, 09.11.04/16.11.04 | Practical: Fluorescence Spectrosocpy |
Downloads: Literature 1, Literature 2 | |
Session 7, 23.11.04 | Paper Presentations |
Downloads: Talks |