Research
Update: 23.05.2017

General Research Interests
Research in our laboratory focusses at understanding structure-function relationships of proteins involved in infectious diseases.

Capitalising on genome and transcriptome data sets of pathogenic species, we seek to identify proteins that are either unique to those organisms or posses unique structure-function mechanisms when compared to host organisms. The objective is to then develop therapeutic avenues targeting those proteins, either with small-molecules or vaccines.

Using rigorous biochemical, biophysical and structural methodologies, we conduct structure-function studies to obtain a solid understanding of molecular mechanisms. This knowledge is then applied in order to further projects into structure-based drug and/or vaccine design. The central aspect of all projects is the three-dimensional structure of proteins and their complexes, which forms the basis to understand mechanisms on the molecular level.

To underpin ongoing work, we develop practical software that are made available to the community.

Projects
Annexins
Bioactive compounds
Cyclic Nucleotide
Phosphodiesterases
Cytoskeletal Proteins
Drug Discovery and Design
Electron Transfer and RedOx
Java Applications
Overview
Prohibitins
Proteins for Biotechnological Applications and
Protein Engineering
Proteins in
Infectious
Diseases
Proteins in
Neurological
Diseases
Vaccine Design