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Our research focuses on the structure-function relationships of proteins involved in health and disease.
The current projects comprise proteins involved in infection, inflammation, neurodegeneration, cell development and cell growth.
Cytoskeletal proteins and proteins residing at membrane sites are of special interest to our group.
The central aspect of all projects is the three-dimensional structure of proteins and their complexes,
which forms the basis to understand mechanisms on the molecular level.
In order to correlate structural
information with molecular function, we use a range of techniques spanning from structural
(X-ray crystallography, X-ray scattering, X-ray/neutron reflectometry, molecular modelling) to biophysical methods
(circular dichroism, fluorescence spectroscopy, hydrodynamic methods, calorimetry).
Molecular biology, as well as preparative and analytical biochemistry, play a key role in all projects
to ensure the production of recombinant protein material.
Our group maintains a network of productive collaborations on a variety of projects as well as specialist techniques.
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Please find here a list of publications, awards, and a summary of
recent results.
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